Development of a Population Pharmacokinetic Model Characterizing the Tissue Distribution of Resveratrol After Administration by Different Routes and Doses in Rats.

Studies have demonstrated that resveratrol exerts several pharmacological effects. However, the pharmacokinetic parameters are not completely established. This study describes the plasma pharmacokinetics and tissue distribution of resveratrol after administration by different routes and doses in rats.

Pterional vs. mini-pterional craniotomy for intracranial aneurysms: a systematic review and meta-analysis.

The mini-pterional craniotomy (mPT) was designed to be a minimally invasive alternative to the standard pterional (PT) approach. However, it remains unclear which technique produces better results. Thus, we aimed to perform a meta-analysis comparing functional, surgical, and aesthetic outcomes between mPT and PT in intracranial aneurysms.

Pesticides in rainwater: A two-year occurrence study in an unexplored environmental compartment in regions with different land use in the State of São Paulo - Brazil.

Brazil's extensive agricultural area makes it the world's leading soybeans and sugarcane producer. Therefore, the use of large amounts of pesticides directly impacts all environmental compartments, including rainwater. We analyzed 14 pesticides and 5 degradation products in rainwater from three cities in the State of São Paulo, southeastern Brazil, with distinct land uses.