[Modern notions about the role of taurine in the central nervous system].

Literature data concerning modern notions about the role of taurine in the central nervous system are analyzed. Mechanisms of the neuroprotective activity of taurine are described. Evidence showing the effects of taurine as neurotransmitter, neuromodulator, antioxidant, etc.

[Effect of a new derivative of glutamic and apovincaminic acids on brain metabolism in post-ischemic period].

Neuroprotective properties of the new derivative of glutamic and apovincaminic acids, ethyl -(3-alpha,16-alpha)-eburnamenin-14-carbopxylate of 2-aminopentadionic acid (LHT 1-02) were studied on a model of acute brain ischemia in cats. LHT 1-02 has proved to be more effective than the reference drugs vinpocetin and glycine in preventing the reperfusive damage, which was manifested by decreased postischemic hyperglycemia, activated utilization of oxygen in the brain, and suppressed postischemic metabolic lactate acidosis. Thus, the results of this comparative study show expediency of further investigations of LHT 1 - 02 as a potential neuroprotective drug.

[The comparative investigation of antihypoxia activity of glutamic and N-acetylglutamic acids].

Comparative study of antihypoxic activity of glutamic and N-acetylglutamic acid in doses of 1, 10, 50 and 100 mg/kg was realized. It was experimentally ascertained that the most apparent antihypoxic action of study objects occurs in conditions of hypobaric hypoxia of acetylated derivative of glutamic acid considerably exceeds glutamic acid.

[Effect of magnesium sulfate on characteristics of cerebral hemodynamics under conditions of postischemic brain injury].

Effect of magnesium sulfate (50 and 100 mg/kg) as a corrector of postishemic brain injury has been experimentally studied. It is established that both therapeutic and preventive introduction of magnesium sulfate limits early postishemic hypoperfusion and hypotension.

Interactions between bioactive ferulic acid and fumed silica by UV-vis spectroscopy, FT-IR, TPD MS investigation and quantum chemical methods.

The interactions of bioactive ferulic acid with fumed silica were studied by UV/vis spectroscopy, FT-IR, TPD MS techniques and quantum chemical methods. It was found that surface complexes may form through phenol or carboxyl group of ferulic acid depending on its coverage value. The structure of surface complexes and mechanisms of the ferulic acid chemosorption on the silica surface are discussed.