New area of occurrence of human brucellosis in Brazil: serological and molecular prevalence and risk factors associated with Brucella abortus infection.

Background: Brucellosis is a re-emerging underdiagnosed zoonosis that has significant relevance, especially in developing countries. This study aimed to report the first cases of human brucellosis in the state of Paraíba, Brazil, and to determine the prevalence and risk factors associated with Brucella abortus infection in slaughterhouse workers.

Methods: A cross-sectional study was carried out from December 2021 to February 2022 in public and private slaughterhouses in the state of Paraíba.

Histologic characterization of fracture repair process in wild birds in association with gross appearance of the bone lesion.

This study aims to provide an in-depth examination of the histological changes that occur during the repair of untreated bone fractures in avian species, correlating these microscopic alterations with gross anatomical characteristics observed during different tissue repair phases. A total of 93 bone fractures from different wild birds were analyzed and classified based on temporality (acute, subacute, and chronic) according to the color changes of the hematoma and morphology (open or closed; simple, comminuted, or greenstick fractures). From a microscopic standpoint, a strong correlation was observed between the temporal progression observed macroscopically and the histological changes evident in each temporal category.

Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency: clinical, biochemical and molecular characteristics and long-term outcomes.

Introduction: 11β-hydroxylase (11β-OH) deficiency is the second most frequent cause of classic congenital adrenal hyperplasia (CAH) (5%-8% of cases). Clinically, it is characterized by virilization and arterial hypertension. The objective of this study was to describe the clinical, biochemical and genetic characteristics classic 11β-OH deficiency in patients managed in our hospital and its outcomes.

Fungal infection monitoring on corneal epithelium ex vivo model and its collection over polyethersulfone membrane for detecting Candida albicans and Aspergillus fumigatus.

In this paper we report a human ex vivo model of Aspergillus fumigatus and Candida albicans infection of the cornea. We demonstrate the ability to monitor fungal growth on the cornea through optical and immunofluorescence microscopy. Additionally, we establish a method for collection of fungal antigens in polyethersulfone (PES) membrane-based sample collectors from the surface of fungal inoculated corneas.