[Transgenic cell cultures that synthesize neurotrophic factors and the possibility of therapeutic use of its cells].

Under the leadership of Corresponding Member of the Russian Academy of Sciences L.I. Korochkin, the Laboratory of Neurogenetics and Developmental Genetics (Institute of Gene Biology, Russian Academy of Sciences) for many years has been conducting studies of nervous system development, neural cell differentiation, and application of gene and cell technology to cure neurodegenerative diseases.

New calretinin-positive cells with polymorphous spines in the mouse forebrain during early postnatal ontogeny.

Immunohistochemical studies of calretinin (CR) in forebrain structures adjacent to the anterior horn of the lateral ventricle in adult mice allowed us to detect a population of previously unknown mono- and bipolar cells whose bodies and processes were coated with polymorphous spines (PS) (Morfologiya, 135, No. 3, 7-19 (2009)). CR-positive spiny (CR(+)PS) cells did not contain GAD67 and were located in the white matter and layers V-VI of the frontal area of the dorsomedial cortex close to the cingulum, the rostrodorsal part of the caudate-putamen, the anterior olfactory nucleus, and the subependyma of the dorsolateral angle of the lateral ventricle.

A new population of calretinin-positive cells, presumptively neurons, with polymorphous spines in the mouse forebrain.

An immunohistochemical reaction was used to study the locations of calretinin-positive cells on frontal sections of the anterior part of the mouse cerebral cortex. A previously undescribed population of cells with a characteristic structure was found at the anterior horns of the lateral ventricles. These cells had small (8-10 microm) round bodies giving rise to one and occasionally two nodose processes bearing rare polymorphous spines (PS) and thickenings of irregular shape.

[A novel population of calretinin-positive, presumably non-neuronal, cells with the polymorphous spines in mouse forebrain].

Using the immunocytochemical method, the localization of calretinin-positive cells was studied in the frontal sections of anterior portion of the mouse cerebral hemispheres. The population of cells with a characteristic structure, that was not described previously, was detected in the area of anterior horns of lateral brain ventricles. These cells have small (8-10 microm) rounded perikarya which gave rise to 1 or, rarely, 2 nodose processes covered with widely spaced, polymorphous spines (PS) and irregular thickenings.