Publications by authors named "V E McGilligan"
Article Synopsis
- Cellular senescence refers to the permanent halt of cell growth caused by factors like genetic mutations or damage, and it's linked to aging and diseases like diabetes and heart issues.
- The study aimed to identify specific senescence biomarkers in patients with acute kidney injury (AKI) and chronic kidney disease (CKD) using OLINK proteomics.
- The proteins CKAP4 and PTX3 were found to be significantly elevated in AKI and CKD patients, suggesting they could serve as important indicators for kidney disease progression.
Article Synopsis
- The COVID-19 pandemic has challenged global healthcare systems, prompting research into genetic and proteomic markers for better patient prognosis.
- A study analyzed the protein and genetic profiles of 400 hospitalized and 483 non-hospitalized COVID-19 patients, uncovering 224 proteins linked to inflammation and immunity.
- Key proteins like LGALS9 and LAMP3 were identified as significant predictors of severe illness, suggesting these markers could serve as important tools for understanding and treating COVID-19 outcomes.
Predicting the presence of coronary plaques featuring high-risk characteristics using polygenic risk scores and targeted proteomics in patients with suspected coronary artery disease.
Genome Med
March 2024
Background: The presence of coronary plaques with high-risk characteristics is strongly associated with adverse cardiac events beyond the identification of coronary stenosis. Testing by coronary computed tomography angiography (CCTA) enables the identification of high-risk plaques (HRP). Referral for CCTA is presently based on pre-test probability estimates including clinical risk factors (CRFs); however, proteomics and/or genetic information could potentially improve patient selection for CCTA and, hence, identification of HRP.
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- Health organizations are struggling to control the spread of COVID-19, especially regarding high-risk individuals who may need hospitalization, making it crucial to identify key biomarkers related to severe illness.
- The COVID-19 Response Study intends to conduct a multiomics analysis using blood and saliva samples from 1,000 recovered individuals to uncover host susceptibility factors related to SARS-CoV-2 and severe COVID-19 outcomes.
- The study includes a cohort of 519 participants in Northern Ireland with confirmed SARS-CoV-2 infections, as well as a follow-up group to track symptoms and immune responses over the year post-infection, incorporating extensive data collection and analysis methods.
Combining Polygenic and Proteomic Risk Scores With Clinical Risk Factors to Improve Performance for Diagnosing Absence of Coronary Artery Disease in Patients With de novo Chest Pain.
Circ Genom Precis Med
October 2023
Background: Patients with de novo chest pain, referred for evaluation of possible coronary artery disease (CAD), frequently have an absence of CAD resulting in millions of tests not having any clinical impact. The objective of this study was to investigate whether polygenic risk scores and targeted proteomics improve the prediction of absence of CAD in patients with suspected CAD, when added to the PROMISE (Prospective Multicenter Imaging Study for Evaluation of Chest Pain) minimal risk score (PMRS).
Methods: Genotyping and targeted plasma proteomics (N=368 proteins) were performed in 1440 patients with symptoms suspected to be caused by CAD undergoing coronary computed tomography angiography.