Publications by authors named "V E Kelley"
Protein asparagine (N)-glycosylation, which promotes folding and trafficking of cell surface receptors such as the EGFR, has not been considered a viable target in oncology due to the essential and non-redundant enzymatic activities required for glycan synthesis and transfer. In mammals an exception to this rule is the presence of the oligosaccharyltransferase (OST) catalytic subunit paralogs, STT3A and STT3B. Here we delineate the chemical biology of OST inhibitors and develop an approach for limited inhibition of N-glycosylation optimized for downstream effects on EGFR.
View Article and Find Full Text PDFPeriod poverty affects millions of people who menstruate, but there is limited research to fully understand the scope and impact. Societal stigmas and cultural taboos negatively affect menstruation, a natural, biologic process. When unable to afford or find appropriate menstrual products, individuals may resort to alternative, poorer quality items, which increase their risk of infections.
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- * Researchers have developed a new group of FTO inhibitors called the oxetanyl class, which showed improved potency and selectivity compared to previous versions.
- * One of these inhibitors, FTO-43, exhibited strong anticancer effects in models of glioblastoma, leukemia, and gastric cancer, and functioned similarly to known chemotherapeutic agents while also influencing important cancer-related signaling pathways.
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- Myeloid cells, specifically macrophages, play a crucial role in regulating inflammation in synovial joints, particularly in rheumatoid arthritis, where the molecule IL-34 is significantly expressed.
- IL-34 interacts with a newly identified receptor called PTPRZ found on macrophages, and their absence in specific mouse models led to more severe arthritis symptoms.
- IL-34 and PTPRZ work to promote a reparative macrophage phenotype, enhancing the clearance of dying neutrophils and reducing their recruitment to the inflamed joint, ultimately limiting destructive inflammation and joint damage.
This study tested the usability of a non-stigmatizing community-based trauma intervention delivered by trained community members. The Community Resiliency Model (CRM) was taught to a high-crime, low-income community designated as a Mental Health Provider Shortage Area (19 MPSA score). Five groups of Latino, African-American, LGBTQ, Asian Pacific Islander, and Veteran participants (N-57) with a history of complex/cumulative traumas and untreated posttraumatic stress undertook a five-day 40-h CRM training with master trainers.
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