Publications by authors named "V E Golimbet"
[A role of transcription factors in pathogenic processes associated with schizophrenia].
Zh Nevrol Psikhiatr Im S S Korsakova
December 2024
Schizophrenia is a severe mental illness, the etiology and pathogenesis of which are significantly contributed by hereditary factors. Genome-wide association analysis shows that the majority of genetic variants associated with a high risk of schizophrenia are located in regulatory regions of genes. In this brief review, data on the overall structure of the major regulatory regions of genes are summarized.
View Article and Find Full Text PDFObjective: To evaluate the association of polymorphisms in the gene cluster on chromosome 6 with cognitive functions in patients with schizophrenia spectrum disorders and healthy controls.
Material And Methods: Patients with schizophrenia spectrum disorders (=216) and healthy people without a family history of mental disorders (=240) completed a battery of cognitive tests, from which individual indices of cognitive functioning were derived. Associations of the cognitive index with 22 polymorphisms in the genes were assessed using ANCOVA controlling for sex, age, genetic structure of the sample, and polygenic risk scores of schizophrenia and intelligence.
Article Synopsis
- Mesenchymal stromal cells (MSCs) have significant potential in regenerative medicine but face challenges in classification, particularly for those from the pancreas; this study aims to better characterize pancreatic islet-derived MSCs (hPD-MSCs).
- The hPD-MSCs were isolated from donor islets and analyzed through various methods, confirming they possess key MSC features and can differentiate into fat and bone cells, with unique gene expression patterns compared to MSCs from other tissues.
- The findings reveal that hPD-MSCs share similarities with pancreatic stellate cells and identify specific genes related to pancreatic and neural functions, enhancing the understanding of their therapeutic potential.
Article Synopsis
- Chromatin structure plays a crucial role in determining gene expression and cell identity, especially in neurons, through the action of polycomb group (PcG) proteins.
- A study mapping the 3D genome in neuronal and non-neuronal cells from the Wernicke's area shows that neurons have less separation between active and inactive gene regions compared to other brain cells.
- Neuronal cells display unique chromatin interactions, including a specific network of PcG contacts linked to genes that control development, with a distinct pattern of histone modifications that suggest a functional significance of these interactions for neuron identity.
Schizophrenia (SZ) is a common psychiatric neurodevelopmental disorder with a complex genetic architecture. Genome-wide association studies indicate the involvement of several transcription factors, including ASCL1, in the pathogenesis of SZ. We aimed to identify ASCL1-dependent cellular and molecular mechanisms associated with SZ.
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