[Development of carnosine eyedrops and assessing their efficacy in corneal diseases].

Stable eye drops of 5% carnosine have been developed. Trials of the drug on mice, rats, rabbits, and dogs showed it to be well tolerated at both total and local levels. In animals the eye drops did not affect the diameter of the pupil, nor did they increase the intraocular pressure.

[Characterization of the anti-ulcer effectiveness of carnosine].

The protective effect of natural dipeptide carnosine on gastric and duodenal mucosal lesions induced by acetic acid application was studied on rats. An increase in total area of the erosions on the stomach and duodenum was significantly inhibited by oral and intraperitoneal administration of carnosine. In addition, carnosine normalized the level of amino acids undergoing change during gastric mucosal injury.

[Interactions of various amino acids, dipeptides and glutathione with hypochlorite anion (CLO-)].

The specific features of interaction between sodium hypochlorite and various amino compounds were examined. It is shown that in the first reaction munite, methionine and glutathione are the most active in neutralizing hypochlorite anion, while histidine, glycine, alanine, dipeptides and taurine are less active. The chloroamino complexes formed by dipeptides and taurine are the most resistant.