[Anticonvulsive effect of superoxide dismutase].

The influence of superoxide dismutase (SOD) on the development of focal epileptic activity (EpA) in the rat brain cortex has been investigated. Intraperitoneal administration of SOD to rats (1 mg/kg) 30 minutes before penicillin application to the sensorimotor cortex led to marked relaxation of EpA and a decrease in the concentration of lipid peroxidation (LPO) products in EpA focus. The results corroborate our earlier assumption on an important pathogenetic role of LPO disturbances in epileptogenesis and make reasonable the combination of the traditional anticonvulsive therapy with the agents activating the oxidative system.

[Comparative analysis of the concentrations of lipid peroxidation products in the cerebral cortex, cerebrospinal fluid and peripheral blood during epileptic activity].

The development of focal or generalized epileptic activity (EA) in the rat brain cortex leads to the augmentation in the content of lipid peroxidation (LPO) products in the EA area (crude synaptosomes), diene conjugates, TBA-active products (products reacting with 2-thiobarbituric acid), and Schiff bases. LPO activation in the brain cortex during EA leads both to an increase in the level of Schiff bases in the cerebrospinal fluid and to a dramatic rise in the level of diene conjugates and Schiff bases in peripheral blood plasma.

[Effect of nicotinamide on focal and generalized epileptic activity in the cerebral cortex].

Intraperitoneal injection of nicotinamide to rats inhibits epileptic activity induced by penicillin application in the animals' brain cortex. It has been found in experimental primary-generalized epileptic activity induced by bemegride that preliminary injection of nicotinamide increased the latency of the emergence of the first epileptic seizures. Addition of nicotinamide to synaptosomal suspension inhibited accumulation in it of the products of lipid peroxidation.

[Increase in the peroxidation of neuron membrane lipids, one of the pathogenetic mechanisms of epileptic activity].

It was found that the development of the epileptic activity focus induced in rats by application of penicillin to the sensomotor cortex surface was accompanied by an activation of lipid peroxidation in the focus area. An analogous effect was also observed in the development of general convulsive seizures induced in rats by injection of bemegride. Preliminary administration of antioxidants (alpha-tocopherol and ionol) to the animals prevented the effect of lipid peroxidation activation and sharply lowered the penicillin-induced epileptic activity.

[Anticonvulsive effect of the antioxidant ionol].

The influence of the antioxidant ionol on the intensity of epileptic activity in rats has been studied. The epileptic activity was induced by penicillin application to the sensorimotor cortex. It was established that preliminary injection to rats of ionol abolished the effect of lipoperoxidation in the focus of hyperactivity and decreased by a factor of 10(1) the number of seizures recorded on the electrocorticogram in the course of the focus existence.