Publications by authors named "V E Bosio"
Enhancing the biocompatibility and mechanical stability of small diameter vascular scaffolds remain significant challenges. To address this challenge, small-diameter tubular structures were electrospun from silk fibroin (SF) from silk textile industry discarded materials to generate bilayer scaffolds that mimic native blood vessels, but derived from a sustainable natural material resource. The inner layer was obtained by directly dissolving SF in formic acid, while the middle layer (SF-M) was achieved through aqueous concentration of the protein.
View Article and Find Full Text PDFThere are many challenges in the development of 3D-tissue models for studying bone physiology and disease. Silk fibroin (SF), a natural fibrous protein used in biomedical applications has been studied for bone tissue engineering (TE) due to its mechanical properties, biocompatibility and biodegradability. However, low osteogenic capacity as well as the necessity to reinforce the protein mechanically for some orthopedic applications prompts the need for further designs for SF-based materials for TE bone.
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- - The report investigates the effectiveness of dynamic 18F-DOPA PET in evaluating the grading and aggressiveness of pediatric cerebral gliomas, addressing limitations of standard uptake parameters in certain types of tumors.
- - A retrospective analysis of 15 patients assessed both static and dynamic PET parameters to predict tumor grades and survival outcomes, finding that the shape of the time activity curve (TAC) is a strong indicator of low vs. high-grade gliomas.
- - Results showed that TAC accumulation shape was significantly associated with longer progression-free and overall survival, making it a more reliable predictor than traditional static parameters in assessing tumor severity and prognosis.
Cardiovascular diseases are the leading cause of mortality around the globe, and microvasculature replacements to help stem these diseases are not available. Additionally, some vascular surgeries needing small diameter vascular grafts present different performance requirements. In this work silk fibroin scaffolds based on silk/polyethylene oxide blends were developed as microtubes for vasculature needs and for different tissue regeneration times, mechanical properties and structural designs.
View Article and Find Full Text PDFBackground: In the last years several studies have investigated the effects of some air pollutants on cardiovascular diseases (CVD), but the results are not conclusive. Aim of this study was to investigate the association between short-term exposure to ambient air pollution and CVD events in a long-term observational period.
Methods: All CVD events (myocardial infarction - MI and ischemic stroke - IS) which occurred in residents of Como between January 2005 and December 2014 were included.