[Hereditary pancreatitis].

The authors describe a family with hereditary pancreatitis where in three generations in five subjects in the same line complete penetrance of the disease was found. It is the first report on this disease in Czech republic.

Effect of liver damage on the level of coagulation factor II, X and VII in human and bovine plasma.

The thrombin generation test using thromboplastin reagent and synthetic substrate for thrombin and determination of factors II, X and VII using chromogenic substrates were applied to bovine and human plasma from objects with liver disease. The liver damage was accompanied with a lowering of the concentration of at least one factor of the extrinsic pathway of prothrombin activation. Use of some of these methods for laboratory diagnosis of liver damage is proposed.

[Etiology and therapy of cholecystitis and cholelithiasis].

Microscopic examinations of 1,000 ectomized gallbladders in patients with acute acalculous as well as calculous cholecystitides render possible a morphologic definition of the changes which are responsible for the beginning of a disease of the biliary duct. The cases in question are oedema, haemorrhages and necroses in the wall of the gall-bladder. These changes are evoked by pathologic angioneurotic reactions which take place in the supply area of the cystic artery during the gall colic.