Functionalisation and behaviours of polysaccharides conjugated with phenolic compounds by oxidoreductase catalysis: A review.

Polysaccharides have been extensively studied in recent decades. Their conjugation with phenolic compounds of natural origin has demonstrated high added value, not only enhancing certain inherent properties but also introducing new ones. Recently, a sustainable approach utilizing oxidoreductase enzymes (Oxredases) (laccases (Lac), tyrosinases (Tyr) and peroxidases (Per)) has been employed, and interesting progress has been made.

Injectable polyoxazoline grafted hyaluronic acid thermoresponsive hydrogels for biomedical applications.

Injectable thermosensitive hydrogels based on hyaluronic acid (HA) grafted with lower critical solution temperature (LCST) polyoxazoline (copolymers of poly(isopropyl--butyl oxazoline)) or P(iPrOx--BuOx) have been elaborated with tunable solution/gel temperature transitions and gel state elastic modulus. A suitable HA--P(iPrOx--BuOx-67/33)-0.10 sample with an iPrOx/BuOx ratio of 67/33, a polymerization degree (DP) of 25, a substitution degree (DS) of 10%, and displaying thermally induced gelling character with elastic (') and viscous ('') moduli crossover points at 25 °C and a ' at 37 °C around 80 Pa has been chosen for medical application.

Exopolysaccharide from marine microalgae belonging to the genus: fragile gel behavior and suspension stability.

With the aim to find new polysaccharides of rheological interest with innovated properties, rhamnofucans produced as exopolysaccharides (EPS) in a photobioreactor (PBR) and an airlift bioreactor (ABR) by the marine microalgae Glossomastix sp. RCC3707 and RCC3688 were fully studied. Chemical characterizations have been conducted (UHPLC - MS HR).

Lyophilization for Formulation Optimization of Drug-Loaded Thermoresponsive Polyelectrolyte Complex Nanogels from Functionalized Hyaluronic Acid.

The lyophilization of nanogels is practical not only for their long-term conservation but also for adjusting their concentration and dispersant type during reconstitution for different applications. However, lyophilization strategies must be adapted to each kind of nanoformulation in order to minimize aggregation after reconstitution. In this work, the effects of formulation aspects (i.