Inhibition of maturation and function of dendritic cells by intravenous immunoglobulin.

Normal immunoglobulin G for therapeutic use (intravenous immunoglobulin [IVIg]) is used in an increasing number of immune-mediated conditions, including acute and chronic/relapsing autoimmune diseases, transplantation, and systemic inflammatory disorders. Several mutually nonexclusive mechanisms of action account for the immunoregulatory effects of IVIg. Although IVIg inhibits T-cell proliferation and T-cell cytokine production, it is unclear whether these effects are directly dependent on the effects of IVIg on T cells or they are dependent through the inhibition of antigen-presenting cell activity.

Antibodies to C-C chemokine receptor 5 in normal human IgG block infection of macrophages and lymphocytes with primary R5-tropic strains of HIV-1.

In the present study, we demonstrate that normal human IgG for therapeutic use (i.v. Ig) contains natural Abs directed against the CCR5 coreceptor for HIV-1.

[Our experience with the dialysis treatment of phalloides fungal poisoning].

The authors present their practical experience in the treatment of phalloid fungal intoxication via dialysis methods of treatment, included within the complete therapeutic system of that kind exogenous intoxication. The peritoneal dialysis and hemodialysis, with consideration given to the patient's state, enables the reduction of the extremely high lethality. Their early application guarantees higher effectiveness of the dialysis methods of treatment.