Publications by authors named "V Donca"
Background/objectives: Colorectal cancer (CRC) represents one of the most prevalent forms of cancer, with high mortality rates. The aim of this study was to observe and understand the metabolic changes in CRC through targeted metabolomics.
Methods: Samples collected from 58 CRC patients and 35 healthy individuals have been analyzed by liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS), targeting two classes of metabolites: amino acids and acylcarnitines.
The aging population poses a significant challenge to global public health, impacting the physical, mental, and social health of older adults. Social activity has been widely acknowledged as a protective factor for both mental and physical well-being. Research indicates that consistent engagement in social activities can mitigate the risk of depression, prevent cognitive decline, and support physical functionality.
View Article and Find Full Text PDFThe connections between sarcopenia and various chronic conditions, including type 2 diabetes (T2DM), metabolic syndrome (MetS), and liver disease have been highlighted recently. There is also a high occurrence of sarcopenia in metabolic dysfunction-associated steatotic liver disease (MASLD) patients, who are often disregarded. Both experimental and clinical findings suggest a complex, bidirectional relationship between MASLD and sarcopenia.
View Article and Find Full Text PDFThe global demographic trend of population aging is evident across all regions, with a notable increase in the proportion of elderly individuals. Romania exemplifies this phenomenon, as 17% of its population is currently aged 65 years or older-a figure projected to rise to 25% by 2050. This demographic shift underscores the pressing need for comprehensive measures to address the health and social requirements of this growing population segment.
View Article and Find Full Text PDFArticle Synopsis
- The Roma, Europe's largest ethnic minority, face significant health challenges, leading to higher rates of metabolic syndrome and related diseases due to factors like poverty and poor living conditions.
- Over a 36-month study in rural Romanian Roma communities, researchers assessed 343 participants, revealing alarming health statistics, including 32.2% obesity, 54.1% hypertension, and 28.9% prevalence of type 2 diabetes.
- The findings highlight a shift from infectious to metabolic diseases in these communities, stressing the need for targeted public health strategies to address their specific health disparities and improve access to healthcare.