Publications by authors named "V Dissanayake"
Aims: Clopidogrel exhibits substantial variability in therapeutic response, largely contributed by genetic factors. The pharmacogenomic variants data on clopidogrel metabolism in South Asians have been sparsely studied. This study explores the impact of and gene variants on clopidogrel metabolism in Sri Lankans, revealing significant pharmacogenomic insights with broader implications for South Asians.
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- Pharmacogenomics is gaining traction in South Asia, particularly in Sri Lanka, aiming to enhance drug therapies and minimize side effects for patients.
- A comprehensive review analyzed research in Sri Lanka, where studies were classified into categories like clinical correlational, descriptive, and novel assay development; 11 articles and 8 theses were reviewed.
- While progress has been made, additional clinical studies and a wider scope of genomic research are necessary, alongside efforts to address challenges like funding and public awareness, to successfully implement personalized medicine in the region.
Article Synopsis
- - The study analyzed genetic polymorphisms in Sri Lankans to understand variations in responses to immunomodulator drugs used for autoimmune diseases and blood cancers, using data from 670 participants.
- - Among the most common variants, SLC19A1 showed a major presence at 63.3%, while others had varying frequencies, indicating significant genetic diversity compared to global populations.
- - Notably, some variants like MTHFR were less prevalent in Sri Lankans compared to other groups, highlighting unique genetic profiles that could influence drug efficacy and safety in this population.
Article Synopsis
- This case report describes the first documented instance of a child having both mitochondrial encephalomyopathy (a condition affecting muscles and the brain) and nemaline myopathy (a muscle disorder), highlighting their coexistence.
- An 11-year-old Sri Lankan boy, previously healthy, experienced acute neurological symptoms, elevated lactate levels, and imaging results indicative of an acute brain infarction, leading to genetic testing that confirmed both conditions.
- The child's treatment included supportive care, antiepileptics, and supplements, with ongoing monitoring, underscoring the importance of genetic diagnosis for effective management and family counseling.
Article Synopsis
- Anti-cancer drug therapy is crucial for treating cancer but can vary in effectiveness and safety among individuals due to genetic differences, a factor that is not often addressed in Sri Lanka’s treatment guidelines.
- This study investigates pharmacogenomic variants in Sri Lankans by analyzing data from 541 individuals to identify how these genetic variations impact responses to specific anti-cancer drugs.
- Results show that certain genetic variants have notable frequencies in the Sri Lankan population, potentially guiding personalized therapy to enhance treatment outcomes.