Publications by authors named "V Ding"
Sex Differences in Patients Undergoing FFR-Guided PCI or CABG in the FAME 3 Trial.
JACC Cardiovasc Interv
November 2024
Background: Outcomes in women after fractional flow reserve (FFR)-guided percutaneous coronary intervention (PCI) using current-generation drug-eluting stents (DES) compared with coronary artery bypass grafting (CABG) are unknown.
Objectives: This study sought to evaluate differences in clinical outcomes according to sex after FFR-guided PCI with current generation DES compared with CABG.
Methods: The FAME 3 trial was an investigator-initiated, randomized controlled trial, comparing FFR-guided PCI with current generation DES or CABG in patients with 3-vessel coronary artery disease.
Reciprocal interactions between alveolar fibroblasts and epithelial cells are crucial for lung homeostasis, injury repair, and fibrogenesis, but underlying mechanisms remain unclear. To investigate, we administered the fibroblast-selective TGF-β1 signaling inhibitor epigallocatechin gallate (EGCG) to interstitial lung disease (ILD) patients undergoing diagnostic lung biopsy and conducted single-cell RNA-Seq on spare tissue. Biopsies from untreated patients showed higher fibroblast TGF-β1 signaling compared with nondisease donor or end-stage ILD tissues.
View Article and Find Full Text PDFThe functional properties of organic semiconductors are defined by the interplay between optically bright and dark states. Organic devices require rapid conversion between these bright and dark manifolds for maximum efficiency, and one way to achieve this is through multiexciton generation (S→TT). The dark state TT is typically generated from bright S after optical excitation; however, the mechanistic details are hotly debated.
View Article and Find Full Text PDFArticle Synopsis
- A study found that very few young people with type 1 diabetes (T1D) achieve recommended glucose levels, but continuous glucose monitoring (CGM) can help despite inequitable access.
- The 4T Study 1 program was designed to improve glycemia in newly diagnosed youth by using early CGM, remote monitoring, and targeting tighter glucose goals (HbA1c < 7%).
- Results showed that after one year, participants had a mean HbA1c of 6.58% with 64% meeting the target, demonstrating effective care without serious issues, and suggesting these strategies could benefit other chronic conditions.
Background And Purpose: Artificial intelligence models in radiology are frequently developed and validated using data sets from a single institution and are rarely tested on independent, external data sets, raising questions about their generalizability and applicability in clinical practice. The American Society of Functional Neuroradiology (ASFNR) organized a multicenter artificial intelligence competition to evaluate the proficiency of developed models in identifying various pathologies on NCCT, assessing age-based normality and estimating medical urgency.
Materials And Methods: In total, 1201 anonymized, full-head NCCT clinical scans from 5 institutions were pooled to form the data set.