Publications by authors named "V Di Paolo"
We appraise other people's emotions by combining multiple sources of information, including somatic facial/body reactions and the surrounding context. A wealthy literature revealed how people take into account contextual information in the interpretation of facial expressions, but the mechanisms mediating such influence still need to be duly investigated. Across two experiments, we mapped the neural representations of distinct (but comparably unpleasant) negative states, pain and disgust, as conveyed by naturalistic facial expressions or contextual sentences.
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- Primary splenic pregnancy is an extremely rare type of ectopic pregnancy that can lead to severe abdominal bleeding, with only 51 cases documented globally; this study aims to improve diagnosis and treatment options to lower mortality rates.
- The authors present a case study of a 22-year-old woman and conducted a thorough literature review to identify effective treatment methods for primary splenic pregnancy, categorizing findings by clinical presentation and treatment strategies.
- Results showed that most cases (72.7%) were emergencies, with 75% needing splenectomy; the study concludes that treatment should be customized to each patient's conditions, highlighting the need for more evidence-based approaches to care.
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- Researchers are exploring extracellular vesicle (EV)-carried miRNAs as potential biomarkers for assessing tumor aggressiveness and tailoring therapies, due to their stability and tissue specificity.
- A study identified nine miRNAs significantly upregulated in RMS patients, with miR-335-5p showing promise as a marker for distinguishing ARMS from ERMS, correlating with disease severity and patient survival outcomes.
A key challenge in cancer research is the meticulous development of models that faithfully emulates the intricacies of the patient scenario, with emphasis on preserving intra-tumoral heterogeneity and the dynamic milieu of the tumor microenvironment (TME). Organoids emerge as promising tool in new drug development, drug screening and precision medicine. Despite advances in the diagnoses and treatment of pediatric cancers, certain tumor subtypes persist in yielding unfavorable prognoses.
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