Publications by authors named "V De Simone"
Introduction: In recent years, the use of Clear aligners (CA) has been diffused among children and adolescents. This systematic review aimed to summarize the literature regarding the effects of CA therapy in growing patients, including dentoalveolar and skeletal effects, periodontal changes, and quality of life measurements.
Methods: An electronic search on four databases was performed until September 2023, and studies including patients <18 years, treated with CA were selected.
Article Synopsis
- Bone diseases result from an imbalance in bone remodeling due to increased activity of osteoclasts and decreased activity of osteoblasts, and the mevalonate pathway (MVA) is essential for maintaining this equilibrium through the action of the enzyme FPPS.
- FDA-approved nitrogen-containing bisphosphonates (N-BPs) target FPPS, highlighting its importance in treating bone-related diseases, while recent research focuses on developing new FPPS inhibitors using a combination of computational modeling, biochemical assays, and biophysical techniques.
- The study demonstrates that newly designed peptides and phosphopeptides effectively inhibit FPPS, showcasing potential as anti-cancer agents by impacting the MVA pathway in murine colorectal cancer cells.
Crohn's disease (CD) is marked by recurring intestinal inflammation and tissue injury, often resulting in fibrostenosis and bowel obstruction, necessitating surgical intervention with high recurrence rates. To elucidate the mechanisms underlying fibrostenosis in CD, we analyzed the transcriptome of cells isolated from the transmural ileum of patients with CD, including a trio of lesions from each patient: non-affected, inflamed, and stenotic ileum samples, and compared them with samples from patients without CD. Our computational analysis revealed that profibrotic signals from a subset of monocyte-derived cells expressing CD150 induced a disease-specific fibroblast population, resulting in chronic inflammation and tissue fibrosis.
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- - Enteric glia are important players in the tumor microenvironment of colorectal cancer and may influence cancer development.
- - These glial cells change their characteristics to help immune cells like monocytes become more supportive of tumor growth, indicating a complex interaction within the tumor.
- - A higher presence of enteric glia correlates with poorer outcomes in colorectal cancer cases, suggesting their role in disease progression.
: The aim of this study was to assess whether the frequency and presentation modality of hemorrhoidal prolapse may have an impact on patients' quality of life, leading to a different categorization of patients. : A consecutive series of patients affected by primary hemorrhoidal disease were administered specific questionnaires to assess the severity of symptoms and their quality of life. The frequency/modality of prolapse was also assessed, and the classification of the patients into five categories was hypothesized.
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