Effect of listening to music on anxiety, pain, and cardiorespiratory parameters in cardiac surgery: A randomized clinical trial.

Purpose: To evaluate the effect of listening to music on preoperative anxiety, postoperative pain (at rest and during coughing), and cardiorespiratory parameters in patients undergoing cardiac surgery.

Design: Single-centered, randomized, parallel, superiority clinical trial.

Methods: This study was carried out with 50 adult patients undergoing elective cardiac surgery randomly allocated at a 1:1 ratio to one of the groups, experimental (n = 25) or control (n = 25).

M&M: an RNA-seq based pan-cancer classifier for paediatric tumours.

Background: With many rare tumour types, acquiring the correct diagnosis is a challenging but crucial process in paediatric oncology. Historically, this is done based on histology and morphology of the disease. However, advances in genome wide profiling techniques such as RNA sequencing now allow the development of molecular classification tools.

Integrating binding affinity and tonic signaling enables a rational CAR design for augmented T cell function.

Background: The success of chimeric antigen receptor (CAR) T cell therapy for hematological malignancies has not yet translated into long-term elimination of solid tumors indicating the need for adequately tuning CAR T cell functionality.

Methods: We leveraged a translational pipeline including biophysical characterization and structural prediction of the CAR binding moiety, evaluation of cellular avidity, synapse formation, T cell motility, and functional capacities under repetitive target challenge and in sustained tumor control.

Results: As an example of clinical relevance, we derived a panel of anti-Her2 CARs covering a 4-log affinity range, all expected to target the same Her2 epitope.

Impact of Antipsychotic Medications on Weight Gain and Eating Disorder-Related Psychopathology in Adult Inpatients with Anorexia Nervosa.

Introduction: The impact of antipsychotic use on weight gain and eating disorder-related psychopathology in adult inpatients with anorexia nervosa (AN) is unclear.

Methods: Consecutively hospitalized adults with AN were retrospectively analyzed. Co-primary outcomes were body mass index (BMI) and weekly weight change.