[Effect of enkephalins and naloxone on the activity of the kallikrein-kinin system in experimental hemorrhagic shock].

The effect of enkephalin derivates with different receptor subtype specificity and opioid antagonist naloxone on kallikrein-kinin system was studied in anaesthetized rats exposed to 30% hemorrhage. Hemorrhage by itself caused only a slight activation of KKS. Pretreatment with naloxone induced a significant activation of KKS, which was potentiated by subsequent hemorrhage.

Effect of intravenous enkephalin administration on kallikrein-kinin system in experimental hemorrhagic shock. Evidence for activation of kallikrein-kinin system by naloxone.

The effects of enkephalin derivates with different opioid receptor subtype specificity and naloxone on cardiovascular responses and kallikrein-kinin system (KKS) were studied in anesthetized rats exposed to 30% hemorrhage. Administration of a mu-receptor agonist (DAGO) in early hemorrhage improved mean arterial blood pressure (MAP) responses to hemorrhage. This effect could be abolished by naloxone pretreatment.