The Nephroprotective Effect of Nitric Oxide during Extracorporeal Circulation: An Experimental Study.

This study aims to determine the effectiveness of administering 80 ppm nitric oxide in reducing kidney injury, mitochondrial dysfunction and regulated cell death in kidneys during experimental perfusion. Twenty-four sheep were randomized into four groups: two groups received 80 ppm NO conditioning with 90 min of cardiopulmonary bypass (CPB + NO) or 90 min of CPB and hypothermic circulatory arrest (CPB + CA + NO), while two groups received sham protocols (CPB and CPB + CA). Kidney injury was assessed using laboratory (neutrophil gelatinase-associated lipocalin, an acute kidney injury biomarker) and morphological methods (morphometric histological changes in kidney biopsy specimens).

Hydrodynamic and physicochemical phenomena in liquid droplets under the action of nanosecond spark discharges: A review.

This review presents experimental studies of phenomena occurring in droplets of various liquids under the effect of nanosecond spark discharges. Inorganic liquids and liquids of biological origin are considered here. Attention is payed to hydrodynamic and physico-chemical phenomena in droplets, including a movement of sessile droplets on a substrate under the effect of the discharges, internal flows in droplets (excited by the discharges), plasma capillary phenomena, features of the droplets drying under the effect of the discharges, traces (patterns) left by the droplets, exposed to the discharges, on the substrates etc.

Autonomous portable pulsed-periodical generator of high-power radiofrequency-pulses based on gas discharge with hollow cathode.

Portable autonomous generator of high-power RF-pulses based on the gas discharge with hollow cathode has been designed, fabricated, and tested. Input and output characteristics are the following: discharge current amplitude is 800 A, duration of generated RF-pulses is 350 ns, carrier frequency is ∼90 MHz, power in RF-pulse is 0.5 MW, pulse repetition rate is 0.

Influence of NO-containing gas flow on various parameters of energy metabolism in erythrocytes.

We studied the influence of NO-containing gas phase on some parameters of energy metabolism in human erythrocytes. Whole blood samples were aerated with gas flows from the Plazon instrument (NO concentrations 800 and 80 ppm) and from the experimental generator (75 ppm). Activity of lactate dehydrogenase in direct and reverse reactions, lactate level, and a number of derived coefficients were estimated.