Economic evaluation of doravirine/tenofovir disoproxil fumarate/lamivudine for HIV-1-infected adults in Russia: a cost-minimization and budget impact analysis.

Background: In Russia, before 2022, the list of vital and essential drugs for HIV-infected patients previously untreated with antiretroviral drugs included the fixed-dose combination rilpivirine/tenofovir disoproxil fumarate/emtricitabine (RPV/TDF/FTC) but not doravirine/tenofovir disoproxil fumarate/lamivudine (DOR/TDF/3TC).

Methods: An indirect comparison of the efficacy of DOR/TDF/3TC and RPV/TDF/FTC defined by virologic suppression (HIV-1 RNA of <50 copies/mL at week 48) was made. The per-patient drug costs over 1 year were compared in a cost-minimization analysis.

Tuberculosis in HIV-infected children in Europe, Thailand and Brazil: paediatric TB-HIV EuroCoord study.

Setting: Centres participating in the Paediatric European Network for Treatment of AIDS (PENTA), including Thailand and Brazil.

Objective: To describe the incidence, presentation, treatment and treatment outcomes of tuberculosis (TB) in human immunodeficiency virus (HIV) infected children.

Design: Observational study of TB diagnosed in HIV-infected children in 2011-2013.

Coronarographic and pathomorphological characteristics of unstable atherosclerotic plaques in acute coronary syndromes.

The proximal segments of the main coronary vessels are the most often localization of "soft" unstable atherosclerotic plaques. The maximum number of plaques developed in the anterior descending branch of the left coronary artery. Pathognomonic relationship was found between the type of these plaques (with ulceration, rupture, thrombosis) and certain acute coronary syndrome.

Symmetrically tetrasubstituted [2.2]paracyclophanes: their systematization and regioselective synthesis of several types of bis-bifunctional derivatives by double electrophilic substitution.

The possible number of chiral and achiral tetrasubstituted [2.2]paracyclophanes possessing different types of symmetry (C(2), C(i), C(s), C(2v), C(2h)) is evaluated and a unified independent trivial naming descriptor system is introduced. The reactivity and regioselectivity of the electrophilic substitution of the chiral pseudo-meta- and achiral pseudo-para-disubstituted [2.

Pathomorphology of variant relationships between left ventricle and interventricular septum in hypertensive heart.

We carried out complex pathomorphological analysis of hearts (n=640) with pronounced left ventricular hypertrophy accompanied by asymmetric hypertrophy of interventricular septum, which were isolated from patients died of hypertension. The most frequent variants of pathomorphological interrelationships between the left ventricle and interventricular septum in hypertensive hearts were septoconcentric, posteroseptal, and anteroseptal relations. The study revealed alterations in the left ventricle (the state of ventricular cavity, its volume, and structural remodeling) characteristic of each variants and underlying the pathognomonic manifestations in cardio- and hemodynamics.