Publications by authors named "V D Rabinovich"
There are no known drugs or drug combinations that promote substantial central nervous system axonal regeneration after injury. We used systems pharmacology approaches to model pathways underlying axonal growth and identify a four-drug combination that regulates multiple subcellular processes in the cell body and axons using the optic nerve crush model in rats. We intravitreally injected agonists HU-210 (cannabinoid receptor-1) and IL-6 (interleukin 6 receptor) to stimulate retinal ganglion cells for axonal growth.
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- Neurite outgrowth happens when a special receptor called cannabinoid-1 is triggered, causing the entire cell to respond in a coordinated way.
- Researchers studied the different biochemical pathways involved in this response and found many processes that help the cell grow neurites.
- They discovered that some critical processes work deeper in the cell while others are directly related to growing the parts required for neurite extension, meaning many pathways are needed for this growth to happen correctly.
Article Synopsis
- Axonal regeneration in the mature central nervous system (CNS) is hindered by various extracellular factors, even in genetically modified mice that lack key myelin-associated inhibitors.
- Researchers discovered high levels of histone H3 in human cerebrospinal fluid and at injury sites in animal models, indicating it acts as an inhibitor of nerve regeneration.
- Histones inhibit nerve growth by targeting specific receptors and pathways, but this effect can be reversed with activated protein C, which enhances axonal regeneration in damaged nerves.
Article Synopsis
- Iliac vein stenting is an effective procedure to treat iliac vein stenosis, but some patients experience early partial in-stent thrombosis within the first month post-procedure.
- The study analyzed data from 3,518 patients who underwent iliac vein stenting between 2012 and 2018, focusing on factors leading to partial thrombosis, with a follow-up period after the procedure.
- Results showed that while the majority of patients did not experience thrombosis, those with an ASA score of 2 or 3 were at a greater risk for developing partial thrombus, and 18 of the 38 cases of partial thrombus resolved within 3 months.
Article Synopsis
- Iliac vein stenting is a new and effective treatment for chronic venous insufficiency, but in-stent thrombosis is a significant risk, leading researchers to test if Clopidogrel can reduce this risk.
- A study of 3,518 patients analyzed the impact of administering Clopidogrel before and after the stenting procedure compared to after only, tracking 30-day thrombosis rates.
- Results showed no significant difference in thrombosis rates between the two groups, indicating that pre-procedural Clopidogrel may not provide additional benefit in preventing in-stent thrombosis.