Publications by authors named "V D Palumbo"
Breast cancer is the most common cancer and the second leading cause of cancer-related death in women. In advanced stages of the disease, breast cancer can spread and metastasize to the bone, contributing to malignant progression. The roles of tissue stiffness and remodeling of the tumor microenvironment are relevant in influencing cancer progression and invasiveness, but they are still poorly understood.
View Article and Find Full Text PDFBackground: Prostate cancer (PCa) is the second most commonly diagnosed cancer in men worldwide, with metastasis, particularly to bone, being the primary cause of mortality. Currently, prognostic markers like PSA levels and Gleason classification are limited in predicting metastasis, emphasizing the need for novel clinical biomarkers. New molecules predicting tumor progression have been identified over time.
View Article and Find Full Text PDFOsteochondral lesions may be due to trauma or congenital conditions. In both cases, therapy is limited because of the difficulty of tissue repair. Tissue engineering is a promising approach that relies on designed scaffolds with variable mechanical attributes to favor cell attachment and differentiation.
View Article and Find Full Text PDFArticle Synopsis
- - Environmental pollution significantly threatens human health, especially in relation to cardiovascular diseases (CVDs), as highlighted through various studies.
- - Epidemiological research shows a clear link between exposure to various pollutants (air, water, soil) and an increased risk of conditions like hypertension and stroke, while molecular studies identify mechanisms like oxidative stress and inflammation as contributing factors.
- - The review emphasizes the need to understand these connections for developing effective interventions and policies aimed at reducing pollution's negative impacts on cardiovascular health, underscoring the importance of preventive measures for public health.
Cerebral edema (CE) and hemorrhagic transformation (HT) are frequent and unpredictable events in patients with acute ischemic stroke (AIS), even when an effective vessel recanalization has been achieved. These complications, related to blood-brain barrier (BBB) disruption, remain difficult to prevent or treat and may offset the beneficial effect of recanalization, and lead to poor outcomes. The aim of this translational study is to evaluate the association of circulating and imaging biomarkers with subsequent CE and HT in stroke patients with the dual purpose of investigating possible predictors as well as molecular dynamics underpinning those events and functional outcomes.
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