[Hemostasis disorders in patients with pulmonary tuberculosis].

Coagulation studies in 82 patients with pulmonary tuberculosis showed that latent intravascular coagulation occurs not only in patients with active disease, but also in those with marked residual changes. The level of Cl-esterase inactivator may serve as an indicator of the disease prognosis: if its concentration is low, the prognosis is poor. Total fibronectin was measured in 76 patients with different tuberculosis activity.

[Arteriovenous differences in the state of the hemostasis system of patients with pulmonary tuberculosis].

The process of intravascular hemocoagulation in patients with active pulmonary tuberculosis proved to occur both in the microcirculatory bed of systemic circulation and within the organs, in the microvasculature of the affected lung. Enhanced antithrombin III uptake during intravascular hemocoagulation occurring within the organs in the patients and its insufficient reproduction in the vascular bed of the pulmonary circulation are the most important mechanisms responsible for imbalance in the hemostatic system. It has been concluded that the effective influence on the main focus of a specific lesion during the preoperative management of patients and the improvement of liver function will increase the effectiveness of prevention of thrombohemorrhagic complications in the surgical treatment of pulmonary tuberculosis.

[Vitamin E and its structural analogs in tuberculosis].

Efficiency of tocopherol, its analog with a shortened side chain as well as their quinons for tuberculosis was determined. All the studied compounds inhibited peroxide-formation processes in the liver homogenate and mitochondria. The vitamin E amount in the blood is considerably decreased in case of tuberculosis.

[Tocopherol modulation of acetylcholine-induced current in mollusk neurons].

It is shown that vitamin E (tocopherol) and arachidonic acid are antagonists at the cellular level in regulation of Ca-calmodulin-dependent acetylcholine-induced current in molluscan neurons.