Prevention and Management of Chronic Postsurgical Pain and Persistent Opioid Use Following Solid Organ Transplantation: Experiences From the Toronto General Hospital Transitional Pain Service.

Background: With >700 transplant surgeries performed each year, Toronto General Hospital (TGH) is currently one of the largest adult transplant centers in North America. There is a lack of literature regarding both the identification and management of chronic postsurgical pain (CPSP) after organ transplantation. Since 2014, the TGH Transitional Pain Service (TPS) has helped manage patients who developed CPSP after solid organ transplantation (SOT), including heart, lung, liver, and renal transplants.

Autobiographical memory predicts postsurgical pain up to 12 months after major surgery.

Recent cross-sectional studies have identified differences in autobiographical memory (AM) among individuals with chronic pain, but the temporal relationship between the 2 is unknown. Moreover, AM has yet to be studied in patients undergoing major surgery. This study addressed these gaps by conducting a prospective, longitudinal study of memory performance, postsurgical pain, and psychosocial factors in 97 adult participants scheduled for major surgery.

Energy transfer and spatial scrambling of an exciton in a conjugated dendrimer.

Photoexcitation of multichromophoric light harvesting molecules induces a number of intramolecular electronic energy relaxation and redistribution pathways that can ultimately lead to ultrafast exciton self-trapping on a single chromophore unit. We investigate the photoinduced processes that take place on a phenylene-ethynylene dendrimer, consisting of nine equivalent linear chromophore units or branches. meta-Substituted links between branches break the conjugation giving rise to weak couplings between them and to localized excitations.

Coherent exciton-vibrational dynamics and energy transfer in conjugated organics.

Coherence, signifying concurrent electron-vibrational dynamics in complex natural and man-made systems, is currently a subject of intense study. Understanding this phenomenon is important when designing carrier transport in optoelectronic materials. Here, excited state dynamics simulations reveal a ubiquitous pattern in the evolution of photoexcitations for a broad range of molecular systems.

Trapping intermediate MLCT states in low-symmetry {Ru(bpy)} complexes.

The picosecond excited state dynamics of [Ru(tpm)(bpy)(NCS)] ( ) and [Ru(tpm)(bpy)(CN)] ( ) (tpm = tris(1-pyrazolyl)methane, bpy = 2,2'-bipyridine) have been analyzed by means of transient absorption measurements and spectroelectrochemistry. Emissive MLCTs with (GS)HOMO(h)-(GS)LUMO(e) configurations are the lowest triplet excited states regardless of whether 387 or 505 nm photoexcitation is used. 387 nm photoexcitation yields, after a few picoseconds, the emissive MLCTs.