Publications by authors named "V D Dighe"
Article Synopsis
- Ursolic acid (UA) and oleanolic acid (OA) are natural compounds with anti-mycobacterial properties but have poor solubility, limiting their use in treatment.
- Researchers developed solid lipid microparticles (SLMs) to effectively deliver UA and OA, demonstrating their ability to inhibit both drug-sensitive and multidrug-resistant tuberculosis (Mtb) in lab tests.
- In mouse models, the delivery of SLMs via inhalation significantly reduced bacterial loads and improved survival rates without causing toxicity, showcasing their potential as a safe and effective treatment option for tuberculosis.
AKT is one of the overexpressed targets in nonsmall cell lung cancer (NSCLC) and plays an important role in its progression and offers an attractive target for the therapy. The PI3K/AKT/mTOR pathway is upregulated in NSCLC. Acridone is an important heterocycle compound which treats cancer through various mechanisms including AKT as a target.
View Article and Find Full Text PDFPhage Display Identified Novel Leydig Cell Homing Peptides for Testicular Targeting.
ACS Pharmacol Transl Sci
March 2024
Conventional drug delivery methods to treat testicular disorders face various challenges, which could be circumvented by using targeted drug delivery. Testicular cell targeting ligands, such as Leydig cell homing peptides, would be an excellent choice to achieve the targeted delivery of drugs to the testis. In this study, Leydig cell homing peptides (LCHPs), LCHP1 and LCHP2, were identified via in vitro followed by in vivo biopanning of a phage display peptide library and next-generation sequencing.
View Article and Find Full Text PDFCytotoxicity, speedy degradation, and limited cellular absorption are the foremost features influencing the successful delivery of RNAs. Chitosan (Cs) is a polymer that offers an advantage due to its bio-compatibility and biodegradable nature, making it an ideal polycationic vector for delivering siRNA. In this study, chitosan has been modified with arginine in order to increase its encapsulation of siRNA and improve cellular absorption.
View Article and Find Full Text PDFVEGF-A or vascular endothelial growth factor-A is an important factor in enabling neovascularization and angiogenesis. VEGF-A is regulated transcriptionally as well as post transcriptionally. Human antigen R (HuR) belonging to the embryonic lethal abnormal vision (ELAV) family is a key regulator promoting stabilization of VEGF-A mRNA.
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