Scanning electron-microscopic and light-optic investigations of erythrocytes in toxic anaemia.

Detailed assessment of the peculiarities of erythrocyte morphology by applying scanning electron microscopy and light-optics methods gives valuable information on the age characteristics, functional failures of the erythrocyte, pathogenesis of anaemia, and also diagnosis. In toxic anaemia caused by the chronic effect of lead and chlorobenzene there is accumulation of aging erythrocytes in blood that are spherical with rough and folded surfaces, fragmented with protuberances, processes, crypt-like hollows, and holes. In lead intoxication there is increased destruction of erythrocytes; anaemia caused by chlorobenzene is mainly due to a decreased entry of the young forms of the erythrocyte into the blood.