Nano-enabled pharmacogenomics: revolutionizing personalized drug therapy.

The combination of pharmacogenomics and nanotechnology science of pharmacogenomics into a highly advanced single entity has given birth to personalized medicine known as nano-enabled pharmacogenomics. This review article covers all aspects starting from pharmacogenomics to gene editing tools, how these have evolved or are likely to be evolved for pharmacogenomic application, and how these can be delivered using nanoparticle delivery systems. In this prior work, we explore the evolution of pharmacogenomics over the years, as well as new achievements in the field of genomic sciences, the challenges in drug creation, and application of the strategy of personalized medicine.

Design, optimization, and evaluation of methotrexate loaded and albumin coated polymeric nanoparticles.

Methotrexate is a potent anticancer drug whose strong efflux is facilitated by the brain's efflux transporter. As an efflux transporter blocker, albumin increased the drug's concentration in the brain. Methotrexate-loaded nanoparticles were produced by evaporating the emulsification fluid.

Knowledge and awareness of dental implants as a treatment choice in the adult population in North India: A hospital-based study.

Background: Implantology is an emerging field of science, although there are not many subjects who opt for this treatment modality. Replacement of missing or lost teeth with dental prostheses supported by oral implants has been accepted and received positive evaluations from patients who have undergone implant treatment. Today, implant-supported restorations can be considered the treatment of choice from the perspective of occlusal support, preservation of adjacent teeth, and avoidance of a removable partial denture.

Gestational Trophoblastic Disease - Clinicopathological Study at Tertiary Care Hospital.

Introduction: Gestational Trophoblastic Disease (GTD) is a term used for a group of pregnancy-related tumours. These consist of various tumours and tumour like lesions characterized by proliferation of trophoblastic tissue. Amongst GTD, hydatidiform moles are the most common form.

Dentigerous cysts in four quadrants: a rare and first reported case.

The dentigerous cyst is a developmental odontogenic cyst which usually occurs in the second and third decade of life. Dentigerous cyst is one of the most prevalent types of odontogenic cysts associated with partially erupted, developing, or impacted teeth. The mandibular third molars have a high predictability followed by maxillary canines.