Evaluating the implementation and use of a computerized physician order entry system: a case study.

A study at the urology clinic, Frederiksberg Hospital Denmark, the clinicians working procedures, when prescribing, dispensing and administrating drugs using a computerized physician order entry system (CPOE) showed an overwhelming majority of the clinicians who believed it does support the patient safety and quality of treatment despite the CPOE was not used to the expected degre.

Pharmacokinetics of glycosylated recombinant human granulocyte colony-stimulating factor (lenograstim) in healthy male volunteers.

Aims: The aim of this open, randomised, crossover, parallel-group study was to compare the pharmacokinetics and neutrophil responses of lenograstim when administered subcutaneously (s.c.) and intravenously (i.

Fotemustine in the treatment of brain primary tumors and metastases.

Fotemustine is a new chloroethylnitrosourea characterized by the grafting of a phosphonoalanine group onto a nitrosourea radical. Clinical studies using fotemustine have been conducted in malignant glioma, brain metastasis of non-small cell lung cancer, and disseminated malignant melanoma. In recurrent malignant glioma, fotemustine has been used as a single agent: assessed by computed tomography scan, after 8 weeks, the objective response rate was 26.

Fotemustine: an overview of its clinical activity in disseminated malignant melanoma.

Fotemustine is a new chloronitrosourea which is active against disseminated malignant melanoma (DMM), and especially against cerebral metastases (CM). This efficacy has been widely demonstrated through many phase II studies. A multicentre trial of monotherapy was undertaken in 153 evaluable French patients.