[The process of cell degeneration].

It is well conceived that the intention of man in trying to solve human kind ailments, is being a long standing biological rule to give rational solutions at any rate. The response to the current problem studied, approaches a different view of the peripheral and local deteriorating phenomena and offers--in a non classical way--how to maintain the well-being of a population of otherwise healthy women, in trying to defer the degenerative cellular process. Interesting, as the proximity of the XXI century arrives, the technology and the biomedical level of progress seems to be for a way from the ideal, particularly when dealing with a process initiated years before the menopause.

Disturbing the light-darkness pattern reduces circulating testosterone in healthy men.

This is an analytic-sagital-observational-endocrinological study of the environmental stress induced by disturbing the light-darkness pattern. A population of 15 males, ages 28-59 years old, participated at random. All had had a pattern sleep of 22:00-6:00 h.

[Endometrial interference of synthetic estrogens in fertility regulation.Is it necessary to interfere with the antiovulatory mechanism at the central nervous system level in order to obtain contraception?].

For some time the anti-ovulatory activity of certain estrogen/progestagen preparations was the main approach in fertility control. Up to date a drastic dosage reduction of both steroid hormones has been accomplished ameliorating the side effects on the one hand, and being active compounds as contraceptives, in the other. Currently, there are a wide variety of oral contraceptives available with a variety of estrogen doses combined with different progestagens.

[Health status in the population using contraceptives].

In order to partially understand the health status of women under contraceptive therapy and their possible social hazard of it, a descriptive, prospective and transversal study was undertaken in a 500 individuals, ages 20-35 years old, who currently were regulation their fertility. Data were obtained by means of predetermined questions from subjects attending several clinics of the IMSS. Anyone refusing to participate was discharged questions.

Inverted skin changes induced by estrogen and estrogen/glucocorticoid on aging dermis.

To evaluate hormone replacement therapy effects at the peripheral level, the present trial explored the oral effects of mestranol (80 micrograms/day for 10 days) and mestranol plus paramethasone (80 micrograms + 6 mg/day for 10 days) on the skin of postmenopausal women. This double-blind study included 13 patients. Skin biopsies were obtained from the thigh area by a single punch, 5 mm in diameter, before and after treatment, and the sections, six per sample, were micrometrically evaluated.