Publications by authors named "V Cornelius"
Economic evaluation of an adjunctive intraocular and peri-ocular steroid vitreoretinal surgery for open globe trauma: Cost-effectiveness of the ASCOT randomised controlled trial.
PLoS One
December 2024
Background: In the United Kingdom, it is estimated that 5,000 patients sustain eye injuries or ocular trauma requiring hospital admission annually, of which 250 patients will be permanently blinded. This study explores the cost-effectiveness of Adjunctive Steroid Combination in Ocular Trauma (ASCOT) given during surgery versus standard treatment in vitreoretinal surgery in patients with open globe trauma.
Methods: This economic evaluation was embedded alongside the ASCOT RCT (ClinicalTrials.
Background: The burden of over 300 million individuals living with hypertension in India is increasing steadily. Most current guidelines recommend initial combination therapy for effective blood pressure (BP) control. However, there is no randomised evidence to inform which combinations to use in the South Asian population, who account for over one-quarter of the world's population.
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- Randomised controlled trials (RCTs) are essential for assessing the effects of interventions, but there is inconsistency in how researchers describe harmful effects, leading to confusion in terminology.
- A study was conducted with public partners in London and Aberdeen to gather opinions on the terminology used for harmful effects in clinical trials and how these impacts are communicated in both academic and public materials.
- The results showed that public partners preferred the term "side-effect" for all contexts and suggested reserving the term "harm" for more severe adverse events, highlighting a need for clearer communication in the scientific literature.
Introduction: Digital mental health interventions (DMHIs) overcome traditional barriers enabling wider access to mental health support and allowing individuals to manage their treatment. How individuals engage with DMHIs impacts the intervention effect. This review determined whether the impact of user engagement was assessed in the intervention effect in Randomised Controlled Trials (RCTs) evaluating DMHIs targeting common mental disorders (CMDs).
View Article and Find Full Text PDFIntroduction: A minority of school-aged children with asthma have persistent poor control and experience frequent asthma attacks despite maximal prescribed maintenance therapy. These children have higher morbidity and risk of death. The first add-on biologic therapy, omalizumab, a monoclonal antibody that blocks immunoglobulin (Ig)E, was licensed for children with severe asthma in 2005.
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