Publications by authors named "V Corbin"
Article Synopsis
- The ANRS|MIE CoviCompareP study investigated COVID-19 breakthrough infections among vaccinated adults during the Omicron variant's circulation, focusing on those vaccinated with the Pfizer-BioNTech vaccine.
- The study involved healthy adults divided into groups based on previous SARS-CoV-2 infection status and monitored their neutralizing antibodies after vaccination and boosters.
- Results showed that 31% of participants experienced breakthrough infections, with lower infection risks linked to older age, more booster doses, and higher neutralizing antibody levels, especially in those with prior infections.
Comparing ethanol lock therapy versus vancomycin lock in a salvation strategy for totally implantable vascular access device infections due to coagulase-negative staphylococci (the ETHALOCK study): a prospective double-blind randomized clinical trial.
Eur J Clin Microbiol Infect Dis
February 2024
Article Synopsis
- This study aimed to assess the effectiveness and safety of ethanol lock therapy (ELT) versus vancomycin lock therapy (VLT) for treating infections in totally implantable venous access devices (TIVAD) caused by coagulase-negative staphylococci.
- Results showed a treatment success rate of 58.1% for the ELT group and 46.7% for the VLT group, with no significant difference in failure rates between the two therapies.
- The study concluded that both therapies had high treatment failure rates, and emphasizes that removing the TIVAD device is crucial to avoid complications, except in rare cases.
The diversity of COVID-19 disease in otherwise healthy people, from seemingly asymptomatic infection to severe life-threatening disease, is not clearly understood. We passaged a naturally occurring near-ancestral SARS-CoV-2 variant, capable of infecting wild-type mice, and identified viral genomic mutations coinciding with the acquisition of severe disease in young adult mice and lethality in aged animals. Transcriptomic analysis of lung tissues from mice with severe disease elucidated a host antiviral response dominated mainly by interferon and IL-6 pathway activation in young mice, while in aged animals, a fatal outcome was dominated by TNF and TGF-β signaling.
View Article and Find Full Text PDFBackground: Vaccine coverage (VC) in patients awaiting kidney transplantation is insufficient.
Methods: We performed a prospective, single-center, interventional, randomized, open-label study comparing a reinforced group (infectious disease consultation proposed) and a standard group (letter stating vaccine recommendations sent to the nephrologist) of patients in our institution awaiting renal transplantation.
Findings: Out of the 58 eligible patients, 19 declined to participate.
Background And Objective: Lyme disease which is one of the most common infectious vector-borne diseases manifests itself in most cases with erythema migrans (EM) skin lesions. Recent studies show that convolutional neural networks (CNNs) perform well to identify skin lesions from images. Lightweight CNN based pre-scanner applications for resource-constrained mobile devices can help users with early diagnosis of Lyme disease and prevent the transition to a severe late form thanks to appropriate antibiotic therapy.
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