Publications by authors named "V Copie"
HIV-infected cells persisting in the face of suppressive antiretroviral therapy are the barrier to curing infection. Cytotoxic immunoconjugates targeted to HIV antigens on the cell surface may clear these cells. We showed efficacy in mouse and macaque models using immunotoxins, but immunogenicity blunted the effect.
View Article and Find Full Text PDFThe operon encodes a three-protein arsenic resistance system. ArsR regulates the transcription of the operon, while ArsB and ArsC are involved in exporting trivalent arsenic and reducing pentavalent arsenic, respectively. Previous research into 5A has demonstrated that ArsR has regulatory control over a wide range of metal-related proteins and metabolic pathways.
View Article and Find Full Text PDFArticle Synopsis
- - Neurodegenerative retinal diseases like glaucoma and diabetic retinopathy involve the gradual death of retinal ganglion cells (RGCs), driven by mitochondrial dysfunction, oxidative stress, and decreased energy production.
- - Familial dysautonomia (FD) also leads to RGC degeneration, revealing disruptions in mitochondrial structures and energy metabolism that may impact overall visual health, with specific changes in the serum and stool metabolomes indicating systemic deficiencies.
- - The study investigated alterations in retinal metabolites and focused on dopaminergic amacrine cells, which influence RGC activity, using advanced techniques like NMR spectroscopy and mass spectrometry to link these changes to the progressive loss of RGCs in an FD mouse model.
Familial dysautonomia (FD) is a rare sensory and autonomic neuropathy that results from a mutation in the gene. Virtually all patients report gastrointestinal (GI) dysfunction and we have recently shown that FD patients have a dysbiotic gut microbiome and altered metabolome. These findings were recapitulated in an FD mouse model and moreover, the FD mice had reduced intestinal motility, as did patients.
View Article and Find Full Text PDFBackground: The National Cancer Institute issued a Request for Information (RFI; NOT-CA-23-007) in October 2022, soliciting input on using and reusing metabolomics data. This RFI aimed to gather input on best practices for metabolomics data storage, management, and use/reuse.
Aim Of Review: The nuclear magnetic resonance (NMR) Interest Group within the Metabolomics Association of North America (MANA) prepared a set of recommendations regarding the deposition, archiving, use, and reuse of NMR-based and, to a lesser extent, mass spectrometry (MS)-based metabolomics datasets.