Multimethod assessment of children's distress during noninvasive outpatient medical procedures: child and parent attitudes and factors.

The present study assessed behavioral distress during noninvasive outpatient procedures in children ages 4-10 years using a multimethod approach. Factors hypothesized to exacerbate children's distress included parents' and children's attitudes toward healthcare, children's knowledge of medical settings, and parental anxiety. A total of 53 parent-child dyads were recruited from outpatient clinics, with procedural distress assessed via child report, parent report, and direct observation.

Neonatal alloimmune thrombocytopenia may be less severe in a subsequent pregnancy.

Neonatal alloimmune thrombocytopenia (NAIT) is more common than previously appreciated. Clinical presentation is varied, but it is generally a severe disorder and it is said to be more severe in subsequent pregnancies. The authors present a case of fatal disseminated intravascular coagulation that was diagnosed as NAIT only after presentation of a subsequent surviving sibling with intracranial hemorrhage and thrombocytopenia.

Autoimmune thrombocytopenia associated with the first cycle of fludarabine therapy in the treatment of relapsed non-Hodgkin's lymphoma.

Fludarabine phosphate is a purine analogue now commonly used in the treatment of low-grade lymphoid malignancies. An increased incidence of autoimmune haemolytic anaemia is reported with the use of fludarabine for the treatment of chronic lymphocytic leukaemia (CLL). CLL already confers a high risk of autoimmune disorders and, although these are recognized in non-Hodgkiin's lymphoma (NHL), they are less common.