Publications by authors named "V Clergue-Duval"
Article Synopsis
- Current treatment options for psychostimulant use disorder (PUD) are lacking, but research suggests that cholinergic mechanisms could play a role in potential treatments.
- The systematic review evaluates the effectiveness of various cholinergic agents in controlled clinical trials for individuals with PUD, focusing on studies involving cocaine and amphetamines.
- Results indicate that most outpatient trials were inconclusive, with only a couple showing some promise in reducing cocaine use, while laboratory trials did not demonstrate significant effects on cravings or treatment efficacy.*
Background: Cognitive impairments are common in patients with AUD and worsen the prognosis of addiction management. There are no clear guidelines for screening cognitive impairments in hospitalized patients with AUD.
Methods: Fifty-seven patients with an AUD history who were admitted to an acute hospital and assessed by the addiction care team were included.
Objectives: Anxiety and depressive symptoms, as well as cognitive dysfunctions, improve with abstinence in individuals with alcohol use disorders (AUD), but less is known about psychotic features. The objective of this study was to evaluate the psychosis proneness in a sample of individuals with severe AUD and potential changes after alcohol withdrawal.
Method: An observational study was conducted, assessing prospectively Peter's Delusional Inventory scale (PDI); anxiety and depression symptoms by MADRS and cognitive functioning by the MoCA at entry in daycare hospital (D0) and after 30 days (D30).
Aims: Cocaine Use Disorder (CUD) is an important health issue, associated with structural brain abnormalities. However, the impact of the route of administration and their predictive value for relapse remain unknown.
Methods: We conducted an anatomical MRI study in 55 CUD patients (26 CUD-Crack and 29 CUD-Hydro) entering inpatient detoxification, and 38 matched healthy controls.
Background And Objectives: Cocaine is a highly addictive substance, and with no approved medication for cocaine use disorder (CUD), leading to a heavy burden. Despite validated psychosocial treatments, relapse rates after detoxification are very high in CUD. Few consistent factors can predict abstinence after detoxification.
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