Effect of alkyldimethylamine oxides on anaerobic sporulating bacteria of genus Clostridium.

Antibacterial activity of alkyldimethylamine oxides and Iodaminox was determined in vitro in 11 strains of clostridia. The most efficient was (1-methyldodecyl)dimethylamine oxide (MIC = 7.8-78 mumol/L).

Antibacterial activity of N-[2-(dodecanoylmethylamine)ethyl]-alkyl dimethylammonium bromides.

The study contains the results of determination of antibacterial activity of the newly synthesized series of N-[2-(dodecanoylmethylamine)ethyl]-alkyldimethylammonium bromides. The efficiency of the compounds has been characterized towards three species of the genus Clostridium such as Clostridium perfringens, type A, Clostridium bifermentans, Clostridium sporogenes and one strain of the genus Lactobacillus such as Lactobacillus yamanashiensis. The antibacterial activity of the studied compounds has been tested in different time intervals.

[Antibacterial effectiveness of newly synthesized organic ammonium salts, derivatives of dodecanoic acid].

The authors investigated the sensitivity of 10 strains of bacteria genus Clostridium to newly synthetized organic ammonium salts series N-[2-(dodecanoylamino)ethyl] alkyl dimethyl ammonium bromides and N-[2-(dodecanoylamino)ethyl] alkyl dimethyl ammonium bromides. The most effective of the two series of compounds were n-hexyl, n-octyl and n-decyl derivatives, the antibacterial activity of which is comparable with the effectiveness of a selected disinfectant Septonex and is several times greater, as compared with the effectiveness of Ajatin.

Effect of N,N'-bis(alkyldimethyl)-alpha, omega-alkanediammonium dibromides on bacteria of the genus Clostridium.

Antibacterial effect of 17 ammonium compounds of the type of N,N'-bis(alkyldimethyl)-alpha, omega-alkanediammonium dibromides was tested on anaerobically sporulating bacteria of the genus Clostridium. A sizable antibacterial activity was displayed by five N,N'-bis(alkyldimethyl)-1,6-hexanediammonium dibromides and by four N,N'-bis(decyldimethyl)-alpha, omega-alkanediammonium dibromides. These compounds exhibited activity higher than, or comparable with, that of the reference standards Ajatin and Septonex.