Selected Use of Complementary and Alternative Medicine (CAM) Agents in IBD.

Purpose Of Review: Inflammatory bowel disease (IBD) can cause significant psychological, physical, and economic burdens on patients and healthcare systems. Studies show over one-fifth of patients will seek nontraditional methods of treatment for managing their symptoms. Understanding the benefits - and potential harms - of these therapies is important to provide holistic and evidence-based care to our IBD patients.

Perinatal Environmental Risks for Eosinophilic Esophagitis: A Systemic Review and Meta-Analysis.

There are limited data on the association of eosinophilic esophagitis (EoE) and environmental risk factors. The aim of this study was to determine the potential associations between perinatal risk factors and EoE. A search was conducted for relevant studies published up to December 12th, 2023, using MEDLINE, EMBASE, Scopus, Web of Sciences, and Cochrane databases.

The effect of a prospective intervention program with automated monitoring of hand hygiene performance in long-term and acute-care units at a Veterans Affairs medical center.

Objective: To measure the impact of an automated hand hygiene monitoring system (AHHMS) and an intervention program of complementary strategies on hand hygiene (HH) performance in both acute-care and long-term care (LTC) units.

Design: Prospective, nonrandomized, before-and-after intervention study.

Setting: Single Veterans Affairs Medical Center (VAMC), with 2 acute-care units and 6 LTC units.

Fatty Liver Disease and Food Insecurity: Excess in Scarcity.

Purpose Of Review: Nonalcoholic fatty liver disease (NAFLD) is widely prevalent in the U.S and is the primary cause of chronic liver disease. Existing evidence shows that food insecurity may be an independent risk factor for fatty liver disease and is associated with poor health outcomes.

Human T cell generation is restored in CD3δ severe combined immunodeficiency through adenine base editing.

CD3δ SCID is a devastating inborn error of immunity caused by mutations in CD3D, encoding the invariant CD3δ chain of the CD3/TCR complex necessary for normal thymopoiesis. We demonstrate an adenine base editing (ABE) strategy to restore CD3δ in autologous hematopoietic stem and progenitor cells (HSPCs). Delivery of mRNA encoding a laboratory-evolved ABE and guide RNA into a CD3δ SCID patient's HSPCs resulted in a 71.