Publications by authors named "V Chivukula"
Understanding detailed hemodynamics is critical in the treatment of aneurysms and other vascular diseases; however, traditional digital subtraction angiography (DSA) does not provide detailed quantitative flow information. Instead, 1000 fps High-Speed Angiography (HSA) can be used for high-temporal visualization and evaluation of detailed blood flow patterns and velocity distributions. In the treatment of aneurysms, flow diverter expansion and positioning play a critical role in affecting the hemodynamics and optimal patient outcomes.
View Article and Find Full Text PDFFirst In-Vivo demonstration of 1000fps High Speed Coronary Angiography (HSCA) in a swine animal model.
Proc SPIE Int Soc Opt Eng
February 2024
Article Synopsis
- High-speed angiography (HSA) using 1000 fps imaging has been successfully utilized to visualize blood flow in neurovascular systems and is now being tested in cardiovascular systems with a swine model.* -
- A 5 French catheter was inserted into a swine's right coronary artery, and iodine contrast was injected while capturing the imaging at a controlled rate, resulting in effective visualization of blood flow and velocity profiles.* -
- The study highlights the advantages of high spatial and temporal resolution in HSCA, showing potential for determining treatment needs for artery stenoses and suggesting further research into its clinical applications.*
Background: Static cold storage is a mainstay of the heart transplantation (HTx) process. However, the temperature distribution within the organ at each stage of HTx is unknown. In this study, we aimed to quantify how long it took for the heart to warm up and cool down and the nature of temperature distribution with the organ at each stage of HTx.
View Article and Find Full Text PDFBackground: Pediatric heart failure is associated with high mortality rates and is a current clinical burden. There is only one FDA approved pediatric VAD, Berlin Heart EXCOR, for treatment. Thrombo-embolic complications are a significant clinical challenge, which can lead to devastating complications such as stroke and impair efficient EXCOR function.
View Article and Find Full Text PDFArticle Synopsis
- * Researchers used whole-genome sequencing to identify genetic markers that confer resistance to clarithromycin, an antibiotic used for treating anthrax, by isolating resistant mutants derived from a non-infectious strain.
- * They discovered specific genetic mutations in the L22 ribosomal protein that were linked to resistance, highlighting the importance of rapid sequencing for understanding and predicting antimicrobial resistance in anthrax.