Safety assessment of resveratrol surrogate molecule 5 (RSM5): Acute and sub-acute oral toxicity studies in BALB/c mice.

Natural polyphenols have gained greater attention for their potent medicinal properties and potential benefits in addressing various health concerns. Resveratrol, a polyphenolic compound known for its therapeutic properties, has shown limitations in bioavailability, which the novel derivative resveratrol surrogate molecule (RSM5) aims to improve. The present study evaluates the oral toxicity and safety profile of a novel resveratrol derivative through acute and subacute assessments.

Bioinformatics Exploration of the Therapeutic Potential of Lotus Seed Compounds in Multiple Sclerosis: A Network Analysis of c-Jun Pathway.

The central nervous system is affected by multiple sclerosis (MS), a chronic autoimmune illness characterized by axonal destruction, demyelination, and inflammation. This article summarizes the state of the field, highlighting its complexity and significant influence on people's quality of life. The research employs a network pharmacological approach, integrating systems biology, bioinformatics, and pharmacology to identify biomarkers associated with MS.

Exploring the potential of Fargesin from for chronic migraine: and pharmacokinetic study.

Introduction: Chronic migraine is recognized by the WHO as one of the most debilitating chronic conditions. It is primarily caused by central sensitization of the trigeminal nucleus caudalis. Key biomarkers associated with migraine include NFkB, IL-1β, CGRP, and iNOS.