Publications by authors named "V Cena"
Article Synopsis
- - Recent advancements in nanotechnology have led to the creation of various nanostructures, with dendrimers being the most studied, featuring controlled sizes, shapes, and chemical properties.
- - This review highlights the structure, synthesis methods, and cellular uptake mechanisms of dendrimers, and explores their applications as drug carriers for various diseases, including cancer and infections.
- - As nanotechnology continues to evolve, dendrimers are expected to play an increasingly significant role in the pharmaceutical industry, particularly in drug delivery systems, with more compounds moving into clinical trials in the near future.
Article Synopsis
- SiRNA (small interfering RNA) is a special tool that can help scientists turn off specific genes, which is super helpful for studying and treating diseases.
- There are already 5 siRNA treatments approved by the FDA for diseases like high cholesterol and certain nerve problems, showing that these treatments are promising.
- Scientists are working on using siRNA to help even more diseases by delivering them in special tiny packages (lipid-based nanoparticles), which may lead to many new medicines in the future.
Role of cytoblock on pleural effusion for diagnosis of malignant disease.
Diagn Cytopathol
November 2023
Background: Thoracocentesis of pleural effusion is a simple technique for pleural fluid examination through cytology. In addition to cytological examination to assess the nature of pleural fluid content, we can also perform more detailed examinations through cytoblocks of residual fluid. These paraffin-embedded cytoblock samples are important because we can perform examinations as in other bioptic samples.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on creating new colchicine site ligands that effectively combat cancer cells while improving their low water solubility, a common issue with such compounds.
- The new ligands, particularly those featuring a pyridine group and ethylurea or formamide, showed strong antiproliferative effects, especially against challenging glioblastoma cells, demonstrating high selectivity for cancer cells over normal cells.
- Experimental results indicated that these ligands disrupted microtubule networks, led to cell cycle arrest, and ultimately caused cancer cell death through apoptosis, validating their potential as effective anticancer agents.