Publications by authors named "V Calo"
Article Synopsis
- - The implementation guidelines for BRCA1/2 somatic testing do not specifically address predictive testing for bone metastases in metastatic prostate cancer, highlighting gaps in laboratory practice.
- - A multidisciplinary team aims to create a protocol to ensure high-quality nucleic acid extraction from bone metastasis biopsies, focusing particularly on a critical decalcification process.
- - The protocol outlines three key phases: pre-analytical (sample processing), analytical (library preparation for NGS), and post-analytical (reporting genetic variants) to effectively aid clinicians in cancer therapy management using PARP Inhibitors.
Background: The circulating tumor DNA (ctDNA) diagnostic accuracy for detecting phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha () mutations in breast cancer (BC) is under discussion. We aimed to compare plasma and tissue alterations, encompassing factors that could affect the results.
Methods: Two reviewers selected studies from different databases until December 2020.
Background: The incidence of cutaneous melanoma is increasing in Italy, in parallel with the implementation of gene panels. Therefore, a revision of national genetic assessment criteria for hereditary melanoma may be needed. The aim of this study was to identify predictors of susceptibility variants in the largest prospective cohort of Italian high-risk melanoma cases studied to date.
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- Lynch syndrome (LS) is a genetic condition that significantly raises the risk of colorectal cancer and other tumors due to mutations in specific genes.
- The study analyzed clinical and molecular data from 854 colorectal cancer patients to find the most effective ways to identify those at risk for LS through genetic testing.
- It was found that the revised Bethesda guidelines for assessing tissue microsatellite instability were the most reliable selection method, suggesting that a combination of approaches can help better identify LS carriers and minimize the chance of missing a diagnosis.
Background: Hereditary breast cancer (BC), ovarian cancer (OC), and pancreatic cancer (PC) are the major BRCA-associated tumours. However, some BRCA1/2-wild-type (wt) patients with a strong personal and/or family history of cancer need a further genetic testing through a multi-gene panel containing other high- and moderate-risk susceptibility genes.
Patients And Methods: Our study was aimed to assess if some BC, OC, or PC patients should be offered multi-gene panel testing, based on well-defined criteria concerning their personal and/or family history of cancer, such as earliness of cancer onset, occurrence of multiple tumours, or presence of at least two or more affected first-degree relatives.