Publications by authors named "V Calamia"
Objective: Early diagnosis of knee osteoarthritis (KOA) in asymptomatic stages is essential for the timely management of patients using preventative strategies. We develop and validate a prognostic model useful for predicting the incidence of radiographic KOA (rKOA) in non-radiographic osteoarthritic subjects and stratify individuals at high risk of developing the disease.
Methods: Subjects without radiographic signs of KOA according to the Kellgren and Lawrence (KL) classification scale (KL=0 in both knees) were enrolled in the OA initiative (OAI) cohort and the Prospective Cohort of A Coruña (PROCOAC).
Osteoarthritis (OA) is the most prevalent rheumatic pathology. However, OA is not simply a process of wear and tear affecting articular cartilage but rather a disease of the entire joint. One of the most common locations of OA is the knee.
View Article and Find Full Text PDFObjectives: To identify mitochondrial DNA (mtDNA) genetic variants associated with the risk of rapid progression of knee osteoarthritis (OA) and to characterise their functional significance using a cellular model of transmitochondrial cybrids.
Methods: Three prospective cohorts contributed participants. The osteoarthritis initiative (OAI) included 1095 subjects, the Cohort Hip and Cohort Knee included 373 and 326 came from the PROspective Cohort of Osteoarthritis from A Coruña.
Association of the serological status of rheumatoid arthritis patients with two circulating protein biomarkers: A useful tool for precision medicine strategies.
Front Med (Lausanne)
October 2022
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the joints and presence of systemic autoantibodies, with a great clinical and molecular heterogeneity. Rheumatoid Factor (RF) and anti-citrullinated protein antibodies (ACPA) are routinely used for the diagnosis of RA. However, additional serological markers are needed to improve the clinical management of this disease, allowing for better patient stratification and the desirable application of precision medicine strategies.
View Article and Find Full Text PDFArticle Synopsis
- Non-infectious uveitis is a complex condition that can be debilitating, often treated with immunosuppressive drugs, either alone or in combination, though the effectiveness of these strategies has not been directly compared.
- The CoTHEIA study is a significant research project designed to evaluate the safety, efficacy, and cost-effectiveness of methotrexate, adalimumab, and their combination in treating non-infectious non-anterior uveitis, involving 192 participants over a 52-week period.
- Ethical approvals are in place for the study, which will also employ machine learning to identify patient subgroups based on treatment response, and there are plans to widely disseminate the findings to various stakeholders.