Publications by authors named "V CHMELIK"
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View Article and Find Full Text PDFWhat we know and still do not know about tick-borne encephalitis?
Epidemiol Mikrobiol Imunol
October 2021
Tick-borne encephalitis (TBE) is a febrile illness caused by tick-borne encephalitis virus (TBEV), frequently manifesting as inflammation of the central nervous system. TBEV is a typical arbovirus, i.e.
View Article and Find Full Text PDFArticle Synopsis
- Tick-borne encephalitis (TBE) is a significant cause of central nervous system infections in certain European regions, and this study examines clinical data from 555 confirmed TBE patients across eight centers from 2010 to 2017.
- Most patients (37.3% with meningitis, 49.2% with meningoencephalitis) showed a variety of symptoms, with a small percentage experiencing more severe outcomes, including paralysis and even mortality (0.9%).
- The study highlights the severity of TBE and the need for standardized monitoring protocols in endemic areas to capture the disease's full clinical impact, especially since many patients experience incomplete recovery.
We retrospectively assessed the utility of a flow cytometry-based test quantifying the percentage of CD3+ T cells with the CD4-/CD8- phenotype for predicting tularemia diagnoses in 64 probable and confirmed tularemia patients treated during 2003-2015 and 342 controls with tularemia-like illnesses treated during 2012-2015 in the Czech Republic. The median percentage of CD3+/CD4-/CD8- T cells in peripheral blood was higher in tularemia patients (19%, 95% CI 17%-22%) than in controls (3%, 95% CI 2%-3%). When we used 8% as the cutoff, this test's sensitivity was 0.
View Article and Find Full Text PDFObjective: Vancomycin therapeutic drug monitoring (TDM) is recommended for better treatment efficacy and safety. The Scottish Antimicrobial Prescribing Group model recommends weight-based loading dose, next 3-4 doses based on creatinine clearance and maintenance doses according to trough concentrations.
Methods: Retrospective cohort study of all adult patients treated with vancomycin before and after introducing the guideline in a large Czech hospital in 2015 compares the success rate in achieving recommended trough concentrations (10-20 mg/l) during first measurement and efficiency of maintaining these concentrations subsequently.