Publications by authors named "V C Tam"
Background: Vancomycin ranks amongst the most utilized antimicrobial agents in the treatment of serious β-lactam-resistant Gram-positive infections, but its use has been associated with nephrotoxicity. Reduction of acute kidney injury (AKI) has been reported in pre-clinical models with adjuvant montelukast. The purpose of the study was to ascertain if montelukast was associated with a reduction in the prevalence of vancomycin-associated AKI.
View Article and Find Full Text PDFTreatment of serious bacterial infections with antimicrobial agents, such as antibiotics, is a major clinical challenge, because of growing bacterial resistance to multiple agents. Combination therapy (i.e.
View Article and Find Full Text PDFObjective: Cefiderocol is a novel antibiotic used to treat multidrug-resistant bacterial infections. However, there is limited data on its effectiveness for ventriculitis. The objective of this study was to evaluate cefiderocol concentrations in both serum and cerebrospinal fluid (CSF) during the treatment of ventriculitis.
View Article and Find Full Text PDFArticle Synopsis
- Oral mucositis (OM) is a significant complication for nasopharyngeal carcinoma (NPC) patients undergoing radiotherapy, impacting their quality of life, and this study aimed to create a prediction model for severe OM.
- The research involved 464 NPC patients, with a focus on developing a multi-omic model that incorporated clinical, radiomic, and dosiomic features and comparing its effectiveness to a conventional model.
- The multi-omic approach demonstrated better predictive accuracy for severe OM, highlighting the potential for personalized treatment strategies in managing this debilitating side effect in NPC patients.