Publications by authors named "V C R Magalhaes"
Immunogenicity and Safety According to Immunosuppressive Drugs and Different COVID-19 Vaccine Platforms in Immune-Mediated Disease: Data from SAFER Cohort.
Vaccines (Basel)
December 2024
Background/objectives: The effectiveness of COVID-19 vaccine in patients with immune-mediated inflammatory diseases (IMID) depends on the underlying disease, immunosuppression degree and the vaccine regimens. We evaluate the safety and immunogenicity of different COVID-19 vaccine schedules.
Methods: The SAFER study: "Safety and effectiveness of the COVID-19 Vaccine in Rheumatic Disease", is a Brazilian multicentric prospective observational phase IV study in the real-life.
Article Synopsis
- * An analysis of 1,192 participants revealed elevated sACE2 activity following exposure to SARS-CoV-2, especially in children, indicating a significant response regardless of infection status.
- * The research suggests that increased sACE2 activity could help manage SARS-CoV-2 infections, proposing a more nuanced understanding of immune responses beyond traditional infection classifications.
Background: Despite the potential effectiveness of bariatric surgery in promoting weight loss, a considerable proportion of patients still face the challenge of achieving optimal post-surgery outcomes. The timing of eating, in addition to the content of what is eaten, as well as chronotype and social jetlag (a marker of circadian misalignment), have been implicated in weight regulation. However, the current understanding of these chrono-related behaviours in individuals undergoing bariatric surgery is still scarce.
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- The genus Prototheca consists of non-chlorophyll algae that can be harmful to mammals, particularly affecting immunocompromised individuals.
- Researchers studied a case of protothecosis in an HIV patient, identifying the organism as Prototheca wickerhamii through both phenotypic and molecular methods.
- This case marks the first reported instance of systemic human protothecosis in Brazil and emphasizes the need for new detection methods for pathogenic algae in medical settings.
Predictors of Hospitalization in Breakthrough COVID-19 among Fully Vaccinated Individuals with Immune-Mediated Rheumatic Diseases: Data from SAFER-Study.
Vaccines (Basel)
September 2024
Breakthrough COVID-19 (occurring in fully vaccinated people) has been described. Data on its characteristics among immune-mediated rheumatic disease (IMRD) patients are scarce. This study describes breakthrough COVID-19 occurring in IMRD patients participating in the SAFER-study, a Brazilian multicentric cohort evaluating the safety, effectiveness, and immunogenicity of SARS-CoV-2 vaccines in patients with autoimmune diseases.
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