Clinical features, hemorrhage risk and epilepsy outcomes of familial cerebral cavernous malformation: A 20-year observational pragmatic single-center study.

Introduction: Familial Cerebral Cavernous Malformations (fCCMs) are rare, hereditary conditions characterized by multiple central nervous system lesions. Despite their rarity, CCMs can cause significant clinical challenges when symptomatic, manifesting as seizure and symptomatic hemorrhage (CASH). Guidelines suggest neurosurgical intervention for symptomatic or previously symptomatic lesions, while conservative management is recommended for new-onset epilepsy.

Establishment of a Protocol for Viability qPCR in Dental Hard Tissues.

The aim of the study was to establish a live/dead qPCR with propidium monoazide (PMA) that can quantitatively differentiate between viable/non-viable microorganisms in dental hard tissues. Human premolars ( = 88) were prepared with nickel-titanium instruments and incubated with (21 d). Subsequently, the bacteria in half of the teeth were devitalized by heat inactivation (100 °C, 2 h).

Club cell protein (CC16) in serum as an effect marker for small airway epithelial damage caused by diesel exhaust and blasting fumes in potash mining.

Objective: The effect marker club cell protein (CC16) is secreted by the epithelium of the small respiratory tract into its lumen and passes into the blood. Increased amounts of CC16 in serum are observed during acute epithelial lung injury due to air pollutants. CC16 in serum was determined as part of this cross-sectional study in underground potash miners on acute and chronic health effects from exposures to diesel exhaust and blasting fumes.

Multi-proxy assessment of coral reef formation and biotic-abiotic diversity in an urban coastal reef ecosystem in northeastern Brazil.

Coral reefs are habitats with high animal and mineral diversity and are subject to both climate change and anthropogenic impacts. This article presents novel and relevant data on the Seixas coral reef environment's geological, sedimentological, mineralogical, and biotic aspects in Paraíba State, northeastern Brazil. The aim of this study is to evaluate the processes of reef formation and the diversity of coral reef species in urban coastal environments in northeastern Brazil using a multi-proxy approach.

Impact of diesel exhaust exposure on urinary 1-hydroxypyrene in underground salt and potash workers.

Background: Diesel engine exhaust (DEE) and some of the polycyclic aromatic hydrocarbons (PAH) it contains are carcinogenic to humans (for example benzo(a)pyrene) and can cause lung cancer in workers. The objective of this study was to assess exposures to DEE and its component PAH and the potential associations between these two health hazards in a salt and potash mining population.

Methods: Between 2017 and 2019, 1003 underground workers (mining n = 801, maintenance n = 202) and 243 above-ground facility workers from two German mines participated.