Publications by authors named "V Burcia"
Positron emission tomography-computed tomography evaluation for recurrent differentiated thyroid carcinoma.
Eur Ann Otorhinolaryngol Head Neck Dis
October 2012
Objectives: Recurrence is observed in 15-20% of patients under surveillance following treatment of differentiated thyroid cancer (DTC). However, due to cell dedifferentiation, the recurrence may be iodine-negative, thereby compromising detection. For this reason, new methods of exploration are indispensable to enable localization of such recurrences.
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- The study aimed to compare the accuracy of sentinel node biopsy against classical neck dissection and histopathology in staging oral and oropharyngeal T1-T2N0 cancer.
- In a trial with 50 patients, the sentinel node biopsy (SNB) showed a 100% sensitivity and negative predictive value, while the traditional neck staging only had a sensitivity of 50% and a negative predictive value of 78%.
- The findings suggest that the sentinel node biopsy is a superior method for accurately identifying lymph node metastasis in patients with unknown neck disease (cN0), highlighting its potential clinical significance.
Background: Molecular diagnosis has been proposed to enhance the intra-operative diagnosis of sentinel lymph node (SLN) invasion in head and neck squamous cell carcinoma (HNSCC). Although cytokeratin (CK) mRNA quantification with real-time reverse transcriptase-PCR (QRT-PCR) has produced encouraging results, the more discriminating markers remain to be identified.
Methods: Pemphigus vulgaris antigen (PVA), squamous cell carcinoma antigen (SCCA), and CK17 mRNA were quantified using QRT-PCR, and the results were compared with an extensive histopathological examination of the entire SLNs on 78 SLNs harvested from 22 patients with HNSCC.
Background: The tumour grading of primary parotid cancers (PPCs) remains controversial.
Methods: A 20-year standardised single centre treatment has been assessed retrospectively. The histological review of 155 consecutively treated parotid malignancies identified 96 suitable cases for univariate and multivariate survival analyses.