Carbonic anhydrase IX inhibition as a path to treat neuroblastoma.

Background And Purpose: Tumour hypoxia frequently presents a major challenge in the treatment of neuroblastoma (NBL). The neuroblastoma cells produce carbonic anhydrase IX (CA IX), an enzyme crucial for the survival of cancer cells in low-oxygen environments.

Experimental Approach: We designed and synthesised a novel high-affinity inhibitor of CA IX.

Development of multilayered artificial urethra graft for urethroplasty.

To enhance the treatment of patients' urethral defects, such as strictures and hypospadias, we investigated the potential of using artificial urethral tissue. Our study aimed to generate this tissue and assess its effectiveness in a rabbit model. Two types of bioprinted grafts, based on methacrylated gelatin-silk fibroin (GelMA-SF) hydrogels, were produced: acellular, as well as loaded with autologous rabbit stem cells.

Inflammation-suppressing cornea-in-a-syringe with anti-viral GF19 peptide promotes regeneration in HSV-1 infected rabbit corneas.

Pathophysiologic inflammation, e.g., from HSV-1 viral infection, can cause tissue destruction resulting in ulceration, perforation, and ultimately blindness.

Synthesis and characterization of UV curable biocompatible hydrophilic copolymers containing siloxane units.

Tissues are highly three-dimensional structure complexes composed of different cell types and their interactions. One of the main challenges in tissue engineering is the inability to produce large, highly perfused scaffolds in which cells can grow at a high cell density and viability. Poly(dimethyl siloxane) (PDMS) is used as a flexible, biocompatible cell culture substrate with tunable mechanical properties.

Genetic Ablation of Mitigates Cardiac Damage during Experimental Autoimmune Myocarditis in Mice.

Myocarditis (MC) is an inflammatory disease of the myocardium that can cause sudden death in the acute phase, and dilated cardiomyopathy (DCM) with chronic heart failure as its major long-term outcome. However, the molecular mechanisms beyond the acute MC phase remain poorly understood. The ankyrin repeat domain 1 (ANKRD1) is a functionally pleiotropic stress/stretch-inducible protein, which can modulate cardiac stress response during various forms of pathological stimuli; however, its involvement in post-MC cardiac remodeling leading to DCM is not known.