Publications by authors named "V Bucas"
We evaluated celiprolol-induced vasodilatation in aorta taken from 12-week-old spontaneously hypertensive rats (SHR) and the effect of AT(1) angiotensin II receptor antagonism on the vasodilatory action of celiprolol in Wistar Kyoto (WKY) rats and SHR. In WKY rats, the celiprolol-induced relaxation was greatly decreased in denuded aorta, and completely abolished in intact aorta by N(omega)-nitro-l-arginine methyl ester (l-NAME, 100 microM). In SHR, celiprolol-induced relaxation was reduced compared to WKY rats (E(max) (value obtained for the highest concentration, 300 microM)=39.
View Article and Find Full Text PDFThe aims of this study was to characterize the functional response of atypical beta-adrenoceptors (beta-AR) in rat aorta and to investigate whether this relaxation was altered before and during the development of hypertension. Aortic rings from 4 or 12 weeks old Wistar Kyoto (WKY) rats or spontaneously hypertensive rats (SHR) were placed in organ baths and constricted with phenylephrine. Then, cumulative concentration-relaxation curves to the beta-AR agonists were constructed.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the functional expression of beta3-adrenoceptors (beta3-ARs) in equine digital veins (EDVs) and how their relaxation response is affected by endotoxin.
- Samples were taken from the forelimbs of 30 horses, with EDVs being isolated and tested for relaxation responses using various beta3-AR agonists in controlled conditions.
- Results indicated that while beta3-ARs promote relaxation in EDVs, their efficacy is reduced when exposed to endotoxin, suggesting that inflammatory responses may interfere with this mechanism, potentially due to changes in prostanoid production.